Re: MSDS sheets and the Curse of Schiff
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From: | "J. A. Kiernan" <jkiernan@julian.uwo.ca> (by way of histonet) |
To: | histonet <histonet@magicnet.net> |
Reply-To: | |
Content-Type: | text/plain; charset="us-ascii" |
On Wed, 7 Oct 1998
rande_kline/emi/merck@smtp.mail.emindustries.com.emindustries.com wrote:
> Yes, it's true, Schiff's reagent is considered a non-hazardous
> reagent in regards to fire, waste, and reactivity, but it is a
> suspected carcinogen. Basic fuschin is the culprit. If you
> have a U.S. MSDS it may be listed under " Potential Health
> Effects. "
This is just what I was getting at in my earlier
message. Schiff's reagent does not contain any
basic fuchsine. It does contain and release
sulphur dioxide, which is hazardous at high
concentrations, but this is not mentioned in the
MSDS sheet.
From the MSDS writer's point of view,
Schiff probably should be considered a fire
hazard. There would be some pretty nasty fumes
if several gallons of Schiff were released and
heated up in a fire. These guardians of the
public safety tell us that we must wear
protective clothing and respirators if 1 mg
of protein in 1 ml of an antibody solution
should somehow catch fire!
The simple facts are that: (a) Schiff's reagent
in realistic amounts is not a dangerous chemical
(though it can make coloured stains that resist
washing). (b) The MSDS for Schiff is useless
because it has obviously been written by someone
who doesn't know any elementary chemistry and
thinks it's a mixture, not a compound.
(c) MSDS sheets in general are full of irrelevant
and ignorant claptrap. Anyone trying to get
useful information from one in an emergency
would probably asphyxiate, dissolve in the
acid, or spontaneously combust before reaching
the bottom of the first page. (d) MSDS sheets
have a minor use in that they sometimes reveal
the contents of trade-named materials: information
that often cannot be found on bottle labels.
John A. Kiernan,
Department of Anatomy & Cell Biology,
The University of Western Ontario,
LONDON, Canada N6A 5C1
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