[Histonet] Re: Amyloid

From:"Robert Richmond"

I think I've posted to Histonet on this subject before, with no
response - about amyloid controls. Amyloid control tissue is extremely
hard to get, since amyloidosis is quite a rare disease, and very few
autopsies are performed these days. Controls I've seen lately are
usually from surgically resected medullary thyroid carcinomas, but
this is a rare disease also, and something of an off-brand amyloid
(formed from calcitonin) is present in only about 25% of them. The
need to cut fresh sections every time means that blocks are quickly

Amyloidosis of the AA type is rather easily induced in mice - see
for a little information and a brief bibliography (I have no
connection with Sigma-Aldrich).

I would think that this mouse tissue containing amyloid could be used
as a control. Does anyone use it?

Bob Richmond
Samurai Pathologist
Knoxville TN

Histonet mailing list

<< Previous Message | Next Message >>