FAM fixative and immunohistochemistry


Hi all,

I have a question for all of the chemistry and IHC geniuses out there.  I
have a request that specifies formaldehyde-acetic acid-methanol (FAM)
fixation on brain tissue, which after routine processing and paraffin
embedding requires immunohistochemistry.  Early IHC testing on this tissue
has been less than satisfactory.  Does this fixative pose a problem?  Would
10% neutral-buffered formalin be more appropriate?  (Okay, that's two



David A. Reynolds, HT(ASCP)
6605 Merrill Creek Parkway
Everett, WA  98203

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