Re: antibody for axonal degeneration

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From:Abizar Lakdawalla <>
To:Maria Mejia <>
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I'm not sure, maybe some of the histonetters may have a more definitive
You might check references on pericapillary rosettes (in amyotrophic
lateral sclerosis, etc.) which are mostly composed of unmyelinated
degenerated axons.
I have seen the following antibodies used
VIP- Vasoactive intestinal polypeptide
PGP 9.5 - (protein gene product 9.5)
NSE - (Neuron Specific Enolase)
but again I would defer to the experts out there.

Maria Mejia wrote:

> Hello Abzir! Would synaptophsin be the best method to visualize
> axon degenerative fibers, especially unmyelinated, in the mam-
> malian brain? Or would a specific neurofilament or something
> that labels a particular microtubules?
> regards
> Maria Mejia
> Smith-Kettlewell Eye Res. Inst.
> S.F.CA

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