Re: Thioflavin S references needed
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From: | "J. A. Kiernan" <jkiernan@julian.uwo.ca> (by way of histonet) |
To: | histonet <histonet@magicnet.net> |
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On Wed, 20 Jan 1999, Tim Morken wrote:
> Does anyone have references for the original article(s) concerning
> staining amyloid with "Thioflavin S"?
Guntern, R. et 3 al., 1992. An improved thioflavine S
method for staining neurofibrillary tangles and senile
plaques in Alzheimer's didease. Experientia 48: 8-10.
This paper has refs without titles, and it's not clear
which refer to earlier thioflavine S methods. The
modification is a prior permanganate oxidation, which
removes "autofluorescent" background.
Thioflavine S is CI 49010; Direct yellow 7.
Thioflavine T (CI 49005; Basic yellow 1) is a different
dye, also used for amyloid staining.
John A. Kiernan,
Department of Anatomy & Cell Biology,
The University of Western Ontario,
LONDON, Canada N6A 5C1
Phone: (519) 679-2111
FAX (Department): (519) 661-3936
E-mail: kiernan@uwo.ca
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