Re: Thioflavin S references needed

<< Previous Message | Next Message >>
From:"J. A. Kiernan" <> (by way of histonet)
To:histonet <>
Content-Type:text/plain; charset="us-ascii"

On Wed, 20 Jan 1999, Tim Morken wrote:

> Does anyone have references for the original article(s) concerning
> staining amyloid with "Thioflavin S"?

   Guntern, R. et 3 al., 1992. An improved thioflavine S
   method for staining neurofibrillary tangles and senile
   plaques in Alzheimer's didease. Experientia 48: 8-10.
   This paper has refs without titles, and it's not clear
   which refer to earlier thioflavine S methods. The
   modification is a prior permanganate oxidation, which
   removes "autofluorescent" background.

   Thioflavine S is CI 49010; Direct yellow 7.
   Thioflavine T (CI 49005; Basic yellow 1) is a different
   dye, also used for amyloid staining.

 John A. Kiernan,
 Department of Anatomy & Cell Biology,
 The University of Western Ontario,
 LONDON,  Canada  N6A 5C1
   Phone: (519) 679-2111
   FAX (Department): (519) 661-3936

<< Previous Message | Next Message >>