Formalin fixed tissues

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From:MICHELLE LOWE <lowzey@yahoo.com>
To:Histologists <histonet@pathology.swmed.edu>
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I was told by a co-worker: the longer tissue is kept
in formalin, the more it losses its staining
properties.  We were discussing keeping wet tissue vs.
blocks for back up special stain/immunohistochemistry
controls.
  Does it really matter how long the tissue is in   
formalin?
  What are the effects of tissue kept too long in   
formalin?
  It is ideal to have 5-10 year old blocks to use as  
    controls?
I know that this question seems a little generic, but
I'm still a rookie!! :)

Michelle Lowe
Sup. Anatomic Pathology/Histology
Valley Children's Hospital
Madera, CA 
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