I do not remember the source, but I have been told that the most abundant
protein in the human (or other mammalian) body is collagen I.  Most of the
dry weight of a mammal is in the muscles.  Since myosin is actually two
proteins and there are two or three isoforms of it, skeletal muscle alpha
actin is probably the second most abundant protein in the mammalian body.

Allen A. Smith, Ph.D.
Professor of Anatomy
School of Graduate Medical Sciences 
Barry University 
Miami Shores, FL

-----Original Message-----
From: histonet-bounces@lists.utsouthwestern.edu
[mailto:histonet-bounces@lists.utsouthwestern.edu] On Behalf Of Rafael
Garcia
Sent: Friday, January 02, 2004 5:27 PM
To: histonet@lists.utsouthwestern.edu
Subject: [Histonet] most abundent proteins in whole body (or
particulartissue types)


I've exhausted myself looking for some information that seems like it would
be pretty easy to find -- a list or ranking of the most abundant proteins in
the whole body of a mammal (ideally the cow).  One can think of some of the
proteins that should be on the list - the various types of collagen,
osteocalcin, keratin, elastin, actin, myosin, serum albumin, titin,
hemoglobin.  But I've been unable to find even a rough ranking.  

I've found some information on the most abundant proteins in particular
tissues (skeletal muscle and bone), but even this is hard to come by.

If have this type of information (whole body or particular tissue), please
help me out!  

Rafael Garcia
Chemical Engineer
USDA-ARS
Eastern Regional Research Center
600 East Mermaid Lane
Wyndmoor PA 19038
voice: 215-836-3743
fax: 215-233-6795
rgarcia@errc.ars.usda.gov


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