Re: stain for alzheimers

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From:"J. A. Kiernan" <>
Date:Tue, 21 Sep 1999 13:22:12 -0400 (EDT)
Content-Type:TEXT/PLAIN; charset=US-ASCII

> i am looking for a stain to determine alzheimers disease.  would appreciate 
> any suggestions from anybody out there.
> thanks so much, anita
   One of Ferenc Gallyas's silver methods is currently much
   favoured by neuropathologists because of its high sensitivity
   and clean background. 

     Gallyas F & Wolf JR 1986. Metal-catalyzed oxidation renders
       silver intensification selective. J Histochem Cytochem
       34: 1667-1672.

   There is a modification for large (whole human brain sections):

     Braak H & Braak E 1991. Demonstration of amyloid deposits and
       neurofibrillary changes in whole brain sections.  Brain
       Pathol. 1: 213-216.

 John A. Kiernan,
 Department of Anatomy & Cell Biology,
 The University of Western Ontario,
 LONDON,  Canada  N6A 5C1

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