Histology Department
Paterson Institute
Wilmslow Road
Manchester
M20 9BX
UK

-----Original Message-----
From:	Abizar Lakdawalla [mailto:abizarl@innogenex.com]
Sent:	16 September 1999 17:07
To:	Mike Bromley
Subject:	RE: S-100


From:	Abizar Lakdawalla [mailto:abizarl@innogenex.com]
Sent:	15 September 1999 18:33
To:	Mike Bromley
Subject:	RE: S-100

S-100 protein is a member of the EF-hand calcium-binding protein 
superfamily that is widely distributed and conserved in the central 
nervous system of vertebrates. The protein exists in both 
heterodimeric and homodimeric forms.  The two subunits of S-100 
protein are the products of separate genes that are differentially 
expressed by various cells. The beta subunit is present in all S-100 
positive cells and tumors. In contrast, the alpha subunit is 
detectable only in heart, skeletal muscle and brain. In addition to 
its calcium binding properties, S-100 protein has a high-affinity 
binding site for zinc and is involved in the regulation of protein 
phosphorylation in the brain. The protein apparently plays a role in 
cell differentiation and growth, cytoskeletal structure and function, 
and has been implicated in neuropathological diseases.
In addition to glial cells, S-100 protein has been found in normal 
melanocytes, Langerhans cells, histiocytes, chondrocytes, lipocytes, 
skeletal and cardiac muscle, Schwann cells, epithelial and 
myoepithelial cells of the breast, salivary and sweat glands. 
Neoplasms derived from these cells also express S-100 protein to 
varying degrees. A large proportion of well-differentiated tumors of 
salivary gland, adipose tissue, cartilaginous tissue, and Schwann 
cells express S-100 protein. Practically all malignant melanomas are 
positive for S-100 protein.
Abizar
www.innogenex.com

-----Original Message-----
From:	Mike Bromley [mailto:MBromley@PICR.man.ac.uk]
Sent:	Wednesday, September 15, 1999 1:52 AM
To:	abizarl@innogenex.com
Subject:	S-100


Dear All,
I need some information about S-100 protein, I know it is a calcium 
binding protein, but what does it do? Do you have any references etc? 
 Thanks in anticipation.
Sincerely

Mike Bromley PhD
Histology Department
Paterson Institute
Wilmslow Road
Manchester
M20 9BX
UK