Cindy/Cynthia,
	I do a lot of work on mouse tissue especially brain. I have had the
same problem at times and here are my suggsetions:
	1.Try slightly different angle when cutting and float on a lower
temperature water bath for longer. I mean a bath temp as low as 35C and
floating for up to 10 minutes.
	2. How thick are you cutting? If tissue section thickness is not a
major issue might want to try increase or decrease. I generally find thicker
sections more problematic in terms of wrinkles.
	3. If all else fails I would reverse the processing  ie take back
though clearing agents to alcohol and reprocess. I have done this before
when the processor got started on the wrong station.
	4. Fix yourself a good margarita and tell your pathologist there are
always more mice!!

My best guess is that the specimens were not processed in the usual manner.
Best of luck - feel free to contact me via e-mail or phone if you would like
more help.
Cynthia Favara
NIAID/RML/LPVD
903 South 4th Street
Hamilton, MT 59840
PH: 406-363-9317
FAX: 406-363-9286