AW: [Histonet] question about Her2 neu

From:"Gudrun Lang"

We had the problem, that our protocol with the dako-antibody on the
benchmark xt gave also too high scores. You have to validate your protocol
against a "gold-standard". That would be for example the hercep-test. We
switched to the ventana-antibody, with the effect, that the 3+ nearly
disappeard in our statistic.

Gudrun Lang
Biomed. Analytikerin
Akh Linz
Krankenhausstr. 9
4020 Linz
-----Ursprüngliche Nachricht-----
[] Im Auftrag von Green,
Gesendet: Montag, 15. September 2008 15:06
Betreff: [Histonet] question about Her2 neu

First, is there a time frame involved for fixation for formalin issue
when running Her2neu?  If it is FDA approved is it necessary to monitor
it (time frames).  We are having a problem on our trials that the ours
are running higher (ours would be a 1+ vs. 0) than the company we
previously sent them to.  Could it be due to the fact that they don't
have an FDA approved HER 2 neu and maybe not from the same company (we
use Ventana antibodies/equipment) that we use?  Thanks for any help or
pointers in this area.


Please respond to my personal email any responses.


Kathy Green, HT

Manager Histology Laboratory

Holy Spirit Hospital

503 N. 21st Street

Camp Hill, PA  17011

(717) 763-2930

Blackberry:  (717) 370-1726


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