Re: Strange Pigment

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From:Barry Rittman <> (by way of histonet)
Date:Mon, 31 Jan 2000 22:47:05 -0500
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		This is not my area but it sounds as if you may have an
organic dye
pigment in the bladder. Many organic dyes are birefringent. Is it possible
that the acidity of the bladder contents has caused the dye to precipitate
out in the walls of the bladder? Does the kidney have any of this pigment?
Would you be kind enough to send a picture please?

At 03:46 PM 10/30/1999 +0100, you wrote:
>Dear  all, please help.
>We have come across this strange pigment in a bladder biopsy from a patient
>whose bladder appears black on cystoscopy.  Initial diagnosis was melanosis,
>but this clearly is not.  The pigment is blue-black on unstained sections
>and forms small fibres and needle-like crystals.  It is briefringent.  X-ray
>dispersion analysis identified carbon and oxygen - suggesting an organic
>compound.  Furthermore, on the first attempt at EDAX, the EM technician used
>the original slide and upon soaking in xylene for 2 days, the pigment
>Can anyone suggest what the pigment may be, or any methods we could use to
>identify it.
>I have a digital image which I would gladly e-mail to anyone requesting one
>(picture/1000 words and all that).
>Hope you can help
>thanks, Neal.

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