[Histonet] congo red featuring thioflavin-S
From: | Delatour =?iso-8859-1?Q?Beno=EEt?= |
Dear Histoneters,
Does anyone knows the true difference (in terms of specificity/sensitivity)=20
between Congo red and Thioflavin stains for amyloid deposits (eg Abeta
plaques in the brain of Alzheimer's patients or genetically-modified mice
that develop cerebral amyloidosis). In a recent publication I used Congo
red to quantify agregated Abeta deposits but one of the reviewers claimed
that thioflavin was, per sure, more efficient "to provide high contrast to=20
detect even the smallest plaques". From my personal experience I would not=20
share the same conclusions. Has anyone has a bibliographic reference
dealing with differences between the two stains?
Thanks!
Benoît
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