[Histonet] congo red featuring thioflavin-S

From:Delatour =?iso-8859-1?Q?Beno=EEt?=

Dear Histoneters,

Does anyone knows the true difference (in terms of specificity/sensitivity)=20
between Congo red and Thioflavin stains for amyloid deposits (eg Abeta 
plaques in the brain of Alzheimer's patients or genetically-modified mice 
that develop cerebral amyloidosis). In a recent publication I used Congo 
red to quantify agregated Abeta deposits but one of the reviewers claimed 
that thioflavin was, per sure, more efficient "to provide high contrast to=20
detect even the smallest plaques". From my personal experience I would not=20
share the same conclusions. Has anyone has a bibliographic reference 
dealing with differences between the two stains?


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