This is the very first time I recall hearing that methanol might make them crispy! What kind of alcohols do you use?Thanks, jJoyce WeemsPathology ManagerSaint Joseph's Hospital 5665 Peachtree Dunwoody Rd NEAtlanta, GA 30342404-851-7376 - Phone404-851-7831 - Fax-----Original Message-----From: histonet-bounces@lists.utsouthwestern.edu[mailto:histonet-bounces@lists.utsouthwestern.edu]On Behalf Of JoanneMaugerSent: Thursday, October 07, 2004 7:48 AMTo: mbecker@pathlabinc.com; histonet@pathology.swmed.eduSubject: Re: [Histonet] GI bxMichele,Could be crush artifact from clinicians or the gross bench. We use a shorter processing program for GI bxs. Make sure your 95% alc doesn't have methanol in it. This makes bxs very crispy(dries out too much)Drove us crazy too. Jo>>> "Michele Becker"  10/06/04 04:21PM >>>Please help....................  We are having problems with blurring anddistorted nuclei on some of our GI biopsies. This has been happening on andoff for the past few months.  It is not every day and not all the GI bx onany given day. We have ruled out staining and processing. I really think itis something happening to the bxs before we even receive them but want tomake sure we have not left any stones unturned on our end first.  Anysuggestions?Thank-you.Michele_______________________________________________Histonet mailing listHistonet@lists.utsouthwestern.edu http://lists.utsouthwestern.edu/mailman/listinfo/histonet _______________________________________________Histonet mailing listHistonet@lists.utsouthwestern.eduhttp://lists.utsouthwestern.edu/mailman/listinfo/histonetConfidentiality Notice ** The information contained in this message may be privileged and is confidential information intended for the use of the addressee listed above. If you are neither the intended recipient nor the employee or agent responsible for delivering this message to the intended recipient, you are hereby notified that any disclosure, copying, distribution or the taking of any action in reliance on the contents of this information is strictly prohibited. If you have received this communication in error, please notify us immediately by replying to the message and deleting it from your computer.Thank you. Saint Josephs Health System, Inc.