Usually wrinkles are the consequence of poor infiltration or poor microtomy practices more than on the paraffin's quality.
  Check if you have changed anything on your processing schedule or in some of the techs' sectioning habits. Do wrinkles appear on sections from everybody? A section QA program has to be able to identify who prepared the slides.
  René J.

Rebecca Barnhart  wrote:
  Recently we started monitoring slide quality in the histology
department. We have noticed a trend of folds/wrinkles. I have changed
paraffins from Surgipath Blue Ribbon to Fisher's Paraplast X-tra and it
does not seem to have made a difference. I have tired using Halt which
didn't make a difference either. Most of our specimens are GI biopsies,
curettings, skins and breast biopsies. Any other suggestions? Thanks
for the help.

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