Immunohistochemistry is more sensitive (and easier to interpret) than histochemical stains for many infectious disease agents.  I have seen a few cases where the GMS stain was non-diagnostic, but the immunoperoxidase stain for aspergillus revealed unequivocal immunoreactivity.  I have also seen cases where the fungus was diagnosed as aspergillus, but the immunoperoxidase stain was negative, and was subsequently proven to be mucor, once again by immunoperoxidase staining.

Richard

Richard W. Cartun, Ph.D.
Director, Immunopathology & Histology
Assistant Director, Anatomic Pathology
Hartford Hospital
80 Seymour Street
Hartford, CT  06102
(860) 545-1596
(860) 545-0174 Fax

>>> "Johnson, Teri"  12/01/05 09:55AM >>>
Can someone enlighten me why it would be advantageous to use an antibody
against aspirgillus when the silver and PAS techniques work so well?

Teri Johnson
Managing Director Histology Facility
Stowers Institute for Medical Research
1000 E. 50th St.
Kansas City, MO 64133

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