From:Gayle Callis

This is a problem with cytology (PAP) smears when the smear was too thick,
air dried and probably not fixed properly. Parts of the smear literally
peeled off looking like cornflakes, ugh, hope this doesn't ruin appetites
for breakfast cereal!  

Are they letting their biopsies dry out before immersion into fixative???
and/or overprocessing of smaller biopsies?  Possibly overheating the tiny
biopsies when drying sections?  Have seen this happen, or a similar
phenomonem with cartilage (mostly water) that is overprocessed and
overdried in hot ovens but not with brown pigment (from blood?)   

Just some thoughts

Gayle Callis
Histopathology Supervisor
Veterinary Molecular Biology - Marsh Lab
Montana State University - Bozeman
19th and Lincoln St
Bozeman MT 59717-3610

406 994-6367
406 994-4303 (FAX)

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