From:Richard Cartun <>

We have an interesting lesion near the serosal surface in a section of small bowel composed of "signet-ring" -like cells that show immunoreactivity (both nuclear and cytoplasmic) for calretinin.  These same cells are cytokeratin-7 negative; therefore, they are not mesothelial cells.  Any ideas on their lineage?

R. Cartun 

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