Re: [Histonet] Formalin alternative fixative for rodent and large animal

From:Jackie M O'Connor

In my opinion, for pharma research, there is no worthwhile formalin 
substitute that will give consistent IHC results.   I have tried STF 
(which was discontinued) and other subs - finally went back to formalin.
With STF, the morphology of routine H+E's was horrible.    I'm sure there 
are differing opinions out there - after all, this is histonet.

Jackie O' 
Sent by:
05/28/2008 10:12 AM


[Histonet] Formalin alternative fixative for rodent and large animal

Hello histoworld,

Does anyone have any suggestions for altenative fixative to formalin? I 
still need to maintain quality of IHC and H&E stain and morphology. I've 
come across Prefer and Notoxhisto. Are there any others for animal tissue 
that anyone have tried?

Stephanie D. Rivera
Safety Assessment Department
709 Swedeland RD
King of Prussia, PA 19406
phone: 610-270-7340
fax: 610-270-7202
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