RE: [Histonet] RE:Switching from hospital histo to Research

From:"Bernice Frederick"

Addendum to previous: we process most mouse tissue on a 9 hour cycle.
Makes quite a difference- very few crispy critters. 


Bernice Frederick HTL (ASCP)
Northwestern University
Pathology Core Facility
710 N Fairbanks Court
Olson 8-421
Chicago,IL 60611

-----Original Message-----
[] On Behalf Of Gayle
Sent: Monday, May 14, 2007 1:30 PM
To: Linda Jenkins;
Subject: Re: [Histonet] RE:Switching from hospital histo to Research

Dear Linda and Carol,

Another thing - develop an invaluable network of research histotechs to 
help you as you go along.  Histonet is one place to find these people,
in the end, you will spend a lot of time with them in very lengthy
conversations.  Attending NSH workshops and participating in their 
committees has been a huge help to our laboratory, right down on how to
up GLP, and just about any other methodology -

As for Linda, she is one of my invaluable contacts - sharing ideas, 
literature, the lost method, problem solving with individuals like her
only boosts your knowledge but you also become good friends along the
and maybe someday co-present workshops on various reserach related
as we have done.

Enjoy your research experience - and remember to avoid those "crispy 
critters" .

Gayle Callis
Research Histopathology Supervisor
Veterinary Molecular Biology
Montana State University - Bozeman
PO Box 173610
Bozeman MT 59717-3610

At 12:48 PM 5/14/2007, you wrote:
>Hi, Carol!
>         You  stated:
>  " I'm contemplating making a switch from a routine hospital histology

> department to supervising a pharmaceutical research histology dept. 
> working with mostly rodent tissue.  Any opinions, suggestions, or 
> resources anyone would like to contribute would be greatly 
> appreciated.  It seems like a much less stress level than a hospital
> at times,..... so what am I missing or not thinking about as far as
> "problems" in this type of histology?"
>         Well, I made the switch 18 years ago and the thoughts of going

> back to clinical have never entered my mind.  What's not to like?
> pay, better benefits, MUCH less stress,  no more working holidays or 
> weekends unless I choose to do so.  I think the primary ingredient to
> successful transfer is that you must be self motivated and capable of 
> independent work.  In clinical your days are fairly well defined (e.g.

> embed, section, stain, etc.).  In research, you just never know what
> day will bring.  If you like orderly, routine days then you might want
> stay in clinical.  I brought human protocols to my research lab and
> all had to be severely modified.  Rodent tissue is so lean you must 
> modify processing protocols or you will end up with (as Gayle Callis 
> says) "crispy critters".  You will be asked to perform stains you have

> only read about and they will probably need to be modified on top of 
> that. The only thing I really miss is being able to consult with a 
> pathologist and histology colleagues when I encounter problems. Part
> that problem was solved by joining NSH's VIR & Hard Tissue committees 
> where I have bunches of "bonehead buddies" doing the stuff I am.  I
> haven't found a research pathologist - much to my chagrin.
>         I thought I was happy in clinical histology until I entered
> world of research.  Now, I know true happiness!
>         Hope this helps,
>         Linda
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