RE: [Histonet] dermatitis herpetiformis

From:"Marshall Terry Dr, Consultant Histopathologist"

The diagnostic immunologic pattern is granular IgA on the basement membrane region.
Histologically the disease is identical to another in which the IgA is linear (called soundly enough, linear IgA disease), and very similar to bullous pemphigoid in which basement membrane IgG is found.
Your panel should therefore include both.
Immunofluorescence is unfortunately, the only way to go.

Dr Terry L Marshall, B.A.(Law), M.B.,Ch.B.,F.R.C.Path
 Consultant Pathologist
 Rotherham General Hospital
 South Yorkshire

-----Original Message-----
From: Blachford, Sarah - Histopath Main
Sent: 24 May 2004 16:48
Subject: [Histonet] dermatitis herpetiformis

What antibodies do people use for diagnosing this.  And do you use
immunofluorescence or avidin biotin


Northampton General Hospital NHS Trust 
Cliftonville, Northampton NN1 5BD 

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