RE: more antibody searches

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From:"Kellar, Eric" <kellarec@MSX.UPMC.EDU>
To:"''" <>
Date:Thu, 25 Mar 1999 07:30:43 -0500


R&D Systems
614 McKinley Place N
Minneapolis, MN 55413
Tel: 1-800-343-7475
        (612) 379-2956
Fax: (612) 379-6580

ACTR-1 & 2
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Pleasant Hill Road 
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phone (800) 631-9384 
      or  (973) 584-7093 
ax     (973) 584-0210

Eric Kellar
University of Pittsburgh Medical Center

	From: []
	Sent:  Wednesday, March 24, 1999 4:50 PM
	To:  kellarec@MSX.UPMC.EDU
	Subject:  more antibody searches

	Eric et al,
	Do you know where I could find antibodies to bone morphogenic
	BMPR-1A  also known as ALK3, BRK1 
	BMPR-1B also known as ALK6, BRKII, RPK-I
	BMPII receptor also known as ACTR-II
	Another BMP receptor known as ACTR-I 
	Patsy Ruegg

			-----Original Message-----
			From:	Kellar, Eric [mailto:kellarec@MSX.UPMC.EDU]
			Sent:	Tuesday, March 23, 1999 12:03 PM
			To:	'Histonet'; 'Drew Sally A.'
			Subject:	RE: CR43/3? or CR3/43? Or?


			The Microglia home page is a nice source -

			                 CCR3 and CCR5 are Co-Receptors for
			                 Infection of Microglia

			                 He, Jianglin; Chen, Youzhi; Farzan,
	Michael; et al.

			                 The three chemokine co-receptors
known to
	be involved in
			                 infection--CCR5, CXCR4, and
CCR3--are found
	in various
			types of cells and
			                 tissues. Resistance to HIV-1
infection has
	been linked to
			defective CCR5
			                 alleles, suggesting that CCR5 plays
	important role in
			HIV-replication in the
			                 body. In the central nervous system
	HIV-1 targets
			brain cells known
			                 as microglia and causes
	dementia. Researchers
			now report that
			                 these target cells express both
CCR3 and
	CCR5. The
			researchers found that
			                 the CCR3 ligand, eotaxin, and an
			inhibited HIV-1
			                 infection in the brain cells, as
did a CCR5
	ligand. The
			authors suggest that both
			                 co-receptors promote HIV-1
infection of the
	CNS and that
			the identification of
			                 CCR3's role in the infection of
	may lead to new
			treatments for
			                 AIDS-related dementia. 

			 The CDC National Center for HIV, STD, and TB
	makes this
			information available as a public service
			 only. Providing this information does not
	endorsement by the
			CDC. Reproduction of this text is
			 encouraged; however, copies may not be sold, and
the CDC
	National AIDS
			Clearinghouse should be cited as
			 the source. Copyright 1996, Information, Inc.,

			 Eric Kellar
			 University of Pittsburgh Medical Center

			> ----------
			> From: 	Drew Sally
			> Sent: 	Monday, March 22, 1999 4:43 PM
			> To: 	'Histonet'
			> Subject: 	CR43/3? or CR3/43? Or?
			> Is anyone familiar with an antibody to microglia?
	been given the
			> terms CR43/3 or CR3/43...would these be clones of
	something named
			> something
			> else? I would appreciate any help with this, I
don't even
	have any journal
			> articles to refer to....!  
			> Sally Ann Drew, MT(ASCP)
			> U.of Wis. Hosp. & Clinics
			> IHC/ISH  Clin./Research Lab
			> 600 Highland Ave. A4/204-2472
			> Madison, WI 53792-2472
			> Tel. (608)265-6596
			> Fax:(608)263-1568

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