RE: CR43/3? or CR3/43? Or?

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From:"Kellar, Eric" <kellarec@MSX.UPMC.EDU>
To:"'Histonet'" <>, "'Drew Sally A.'" <>
Date:Tue, 23 Mar 1999 14:03:05 -0500


The Microglia home page is a nice source -

                 CCR3 and CCR5 are Co-Receptors for HIV-1
                 Infection of Microglia

                 He, Jianglin; Chen, Youzhi; Farzan, Michael; et al.

                 The three chemokine co-receptors known to be involved in
                 infection--CCR5, CXCR4, and CCR3--are found in various
types of cells and
                 tissues. Resistance to HIV-1 infection has been linked to
defective CCR5
                 alleles, suggesting that CCR5 plays an important role in
HIV-replication in the
                 body. In the central nervous system (CNS), HIV-1 targets
brain cells known
                 as microglia and causes AIDS-related dementia. Researchers
now report that
                 these target cells express both CCR3 and CCR5. The
researchers found that
                 the CCR3 ligand, eotaxin, and an anti-CCR3 antibody
inhibited HIV-1
                 infection in the brain cells, as did a CCR5 ligand. The
authors suggest that both
                 co-receptors promote HIV-1 infection of the CNS and that
the identification of
                 CCR3's role in the infection of microglia may lead to new
treatments for
                 AIDS-related dementia. 

 The CDC National Center for HIV, STD, and TB Prevention makes this
information available as a public service
 only. Providing this information does not constitute endorsement by the
CDC. Reproduction of this text is
 encouraged; however, copies may not be sold, and the CDC National AIDS
Clearinghouse should be cited as
 the source. Copyright 1996, Information, Inc., Bethesda, MD.

 Eric Kellar
 University of Pittsburgh Medical Center

> ----------
> From: 	Drew Sally A.[]
> Sent: 	Monday, March 22, 1999 4:43 PM
> To: 	'Histonet'
> Subject: 	CR43/3? or CR3/43? Or?
> Is anyone familiar with an antibody to microglia?  I've been given the
> terms CR43/3 or CR3/43...would these be clones of something named
> something
> else? I would appreciate any help with this, I don't even have any journal
> articles to refer to....!  
> Sally Ann Drew, MT(ASCP)
> U.of Wis. Hosp. & Clinics
> IHC/ISH  Clin./Research Lab
> 600 Highland Ave. A4/204-2472
> Madison, WI 53792-2472
> Tel. (608)265-6596
> Fax:(608)263-1568

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