RE: CR43/3? or CR3/43? Or?
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From: | "Kellar, Eric" <kellarec@MSX.UPMC.EDU> |
To: | "'Histonet'" <histonet@Pathology.swmed.edu>, "'Drew Sally A.'" <sa.drew@hosp.wisc.edu> |
Reply-To: | |
Date: | Tue, 23 Mar 1999 14:03:05 -0500 |
Content-Type: | text/plain |
Sally,
The Microglia home page is a nice source -
http://www.lrz-muenchen.de/~u792201/www/microglia.html
CCR3 and CCR5 are Co-Receptors for HIV-1
Infection of Microglia
He, Jianglin; Chen, Youzhi; Farzan, Michael; et al.
The three chemokine co-receptors known to be involved in
HIV-1
infection--CCR5, CXCR4, and CCR3--are found in various
types of cells and
tissues. Resistance to HIV-1 infection has been linked to
defective CCR5
alleles, suggesting that CCR5 plays an important role in
HIV-replication in the
body. In the central nervous system (CNS), HIV-1 targets
brain cells known
as microglia and causes AIDS-related dementia. Researchers
now report that
these target cells express both CCR3 and CCR5. The
researchers found that
the CCR3 ligand, eotaxin, and an anti-CCR3 antibody
inhibited HIV-1
infection in the brain cells, as did a CCR5 ligand. The
authors suggest that both
co-receptors promote HIV-1 infection of the CNS and that
the identification of
CCR3's role in the infection of microglia may lead to new
treatments for
AIDS-related dementia.
The CDC National Center for HIV, STD, and TB Prevention makes this
information available as a public service
only. Providing this information does not constitute endorsement by the
CDC. Reproduction of this text is
encouraged; however, copies may not be sold, and the CDC National AIDS
Clearinghouse should be cited as
the source. Copyright 1996, Information, Inc., Bethesda, MD.
Eric Kellar
Histology/Immunohistochemistry
University of Pittsburgh Medical Center
> ----------
> From: Drew Sally A.[SMTP:sa.drew@hosp.wisc.edu]
> Sent: Monday, March 22, 1999 4:43 PM
> To: 'Histonet'
> Subject: CR43/3? or CR3/43? Or?
>
> Is anyone familiar with an antibody to microglia? I've been given the
> terms CR43/3 or CR3/43...would these be clones of something named
> something
> else? I would appreciate any help with this, I don't even have any journal
> articles to refer to....!
>
> Sally Ann Drew, MT(ASCP)
> U.of Wis. Hosp. & Clinics
> IHC/ISH Clin./Research Lab
> 600 Highland Ave. A4/204-2472
> Madison, WI 53792-2472
> Tel. (608)265-6596
> Fax:(608)263-1568
>
>
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