Formalin pigment
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| From: | "Anatech Ltd." <anatech@net-link.net> |
| To: | HistoNet@Pathology.swmed.edu |
| Reply-To: | |
| Date: | Wed, 31 Mar 1999 10:23:24 -0400 |
| Content-Type: | text/plain; charset="us-ascii" |
Hemoglobin will form an isoluble yellow to black pigment under the
following conditions: reducing environment and low pH. Lack of oxygen due
to CO2 euthanasia provides both conditions. Simple death without fixation
also may create these conditions, which is why autopsy spleens frequently
show pigment even after subsequent fixation in NBF.
Thus, unbuffered formalin need not be present for pigment to develop.
Unfortunately, the term formalin pigment is commonly used to describe the
substance.
Dick
Richard W. Dapson, Ph.D.
ANATECH LTD.
1020 Harts Lake Road
Battle Creek, MI 49015
800-262-8324 or 616-964-6450
Fax 616-964-8084
E-mail anatech@net-link.net
http://www.net-link.net/anatech
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