And the most important aspect is that a patient can be denied a clinical trial if this protocol is not followed specifically, j 

-----Original Message-----
From: histonet-bounces@lists.utsouthwestern.edu [mailto:histonet-bounces@lists.utsouthwestern.edu] On Behalf Of Rene J Buesa
Sent: Monday, April 07, 2008 4:47 PM
To: JOHN P COLEMAN; histonet@lists.utsouthwestern.edu
Subject: Re: [Histonet] Surgipath's O-fix for breast fixation.

When a protocol is approved, it is so to be used as approved and does not allow deviations, IF you want to avoid any payment problems.
  It has nothing to do with adequacy, but with fully following the protocol, regardless of any consideration.
  What is accepted is NBF, nothing else.
  René J. 

JOHN P COLEMAN  wrote:
  We routinely use Surgipath's O-fix on breast tissue for subsequent Her-2 testing via IHC and FISH. Is this now disallowed? According to the labeling, O-fix is a formalin based fixative with ethanol and acetic acid added. I would consider it an alcohol based fixative and disallowed only in the absence of the formalin. 


John P.J. Coleman HT(ASCP)QIHC
Clinical Specialist
Anatomic Pathology
Sentara Laboratory Services
Cell/Voicemail(757)335-2159
pager: (757)456-6695
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