Re: [Histonet] Intranuclear inclusions

From:Rene J Buesa

A change in the "apparent" presence of intraNUCLEAR inclusions can be the result of a change in the fixative or fixation protocol that could determine a change in the nuclear components precipitation.
  Have you had a change in fixation or fixative?
  That could be the explanation.
  René J.

"Secrest, Kimberly"  wrote:
  Hi all,
I have a pathologist who has noticed and an unusual prevelence of intranuclear inclusions in our routine H+E slides. She's noticed it in tissue ranging from a liver biopsy to a skin biopsy.
Has anyone heard of this occuring regularly and what could cause it?

Kimberly Secrest HTL, QIHC
Histology Technical Specialist
West Virginia University Hospital

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