Diana, yes the standard is the Herceptest guideline, as far as I know. I
haven't looked at some of the more recent FDA approved tests.
I highly recommend correlating your scores with Her2 FISH results. Also, if
you have >1 pathologist, the pathologists should periodically review cases
together so that their eyes stay "calibrated" to the same level of
staining/scoring. 


Patti Loykasek BS, HTL, QIHC
PhenoPath Laboratories
Seattle, WA





 I have been out of the loop with Her- 2 for a while, and the last I
> knew, it was left up to the individual labs to establish standards among
> the  interpreting  physicians for interpretation, pretty much based on
> the original Herceptest guidelines.  Have any other standards been
> established?  If so, would someone please provide me with a reference?
> 
> Much obliged,
> Diana Goodwin
> Supervisor, Anatomic Pathology
> Pennsylvania Hospital
> Preston 655-C
> ph. 215-829-6532
> fax 215-829-7564
> e-mail goodwind@[pahosp.com
> 
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