Re: CLO test

From:Mark Frei

The CLO test I'm familiar with is known as a rapid urease test for Helicobacter pylori infection of the gastric antrum.  A biopsy specimen taken during an upper gastrointestinal endoscopy and applied to a substrate pad impregnated with dry urea.  H. pylori bacteria survive in the stomach partly due to the production of urease.  Ammonia is produced by the hydrolysis of urea and this creates a neutral pH micro-environment in the highly acidic stomach.   When incubated, the substrate pad produces ammonia gas which changes the color of a pH indicator.  This is a highly specific test since humans do not produce urease.  

Mark Frei   MT(ASCP)

jill cox <>

03/21/03 10:50 AM

        Subject:        CLO  test

Hi everyone,
 I have a doctor who wants me to look into clo
testing. I was told it is a general lab test. What is
it testing for and can a histology department do it?
Thanks in advance

Jill Cox HT (ASCP)
Seattle Histology Lab

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