I've been having a real problem this last week or so with tissue coming off my Shandon Pathcentre looking "burned," according to my pathologist. What could cause such an artifact? I thought maybe it was a paraffin temp problem, but there's been no record of the processor going outside temp limits. Thought it may be insufficient de-paraffinization (still hoping it's that). It doesn't happen to everything, and the weirdest part is that one level from a biopsy showed the artifact while deeper levels did not.
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