Re: Unusual staining pattern with TTF

From:Patti Loykasek <>

on 3/22/01 3:51 PM, Tom Wells at wrote:

> We recently came across a case that stained strongly positive with Dako TTF,
> but, instead of the usual nuclear staining the staining was cytoplasmic and
> granular.  Has anyone else seen this staining pattern?  We have performed
> numerous TTF stains before and since and have not come across this before.
> Thanks. Tom
> Tom Wells, BSc, ART
> Supervisor, Immunohistochemistry Laboratory
> Lions Gate Hospital
> North Vancouver, BC
> Canada
We have seen this type of granular, cytoplasmic staining with TTF in liver
tissue. Other techs I have talked with have observed this staining pattern,
too. Is the tissue in question liver? I would be interested to know if it is
something else, and add it to my list of artifacts.

Patti Loykasek, HTL, IHC sp
Phenopath Laboratories
Seattle, WA

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