Re: Thio S

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From:Roger Moretz <>
To:LuAnn Anderson <>,
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I cannot find the reference, but there should be a
publication out there by R. Rudelli, et al, mid to
late '80s on the use of Thioflavin S for staining
amyloid.  I have used the method, even have a
published paper somewhere in the archives but not
immediately available (and my Reference Manager is not
responding tonight!!!).  Thio S is fluorescent stain,
similar wavelengths for fluoroscein (again as I
recall-this was a long time ago--you know, 12 years or
more).  It is very sensitive, and is a lot easier to
visualize than Congo Red--no more hunting for that
"apple green birefringence".  I'll try to find the
reference and method over the weekend.

Roger Moretz
Dept of Toxicology

--- LuAnn Anderson <> wrote:
> Hi all!
> I need your help and expertise.  Has anyone out
> there heard of a Thio S for 
> amyloid?  I have done plenty of THio T's but I have
> a new Pathologist who 
> insists that Thio S is different than Thio T and is
> a "standard" staining 
> procedure.  I could not find Thio S in any of my
> Histo books.  Your help is 
> appreciated as always.  Thanks in advance.  LuAnn
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