This is from "Hazardous Materials in the Histopathology Laboratory", by
Dapson (Anatech)
	"Once thought to be quite safe, limonene now is considered to be a
serious health risk for increasing numbers of histotechnologists.  Because
it is a sensitizer, prolonged or repeated exposure predisposes individuals
to allergic reactions.  These generally take the form of respiratory
distress:  difficulty in breathing, tightness in the chest and, in rare
cases, potentially life-threatening anaphylasix."

We had somebody with asthma that did have a problem with the limonene
solvent that we were using.  We replaced it and there were no other problems
(although the person has since left the lab).

> ----------
> From: 	Peter Bannister[SMTP:peterbann@yahoo.com]
> Sent: 	Tuesday, February 29, 2000 5:23 AM
> To: 	NLOUISEA@aol.com
> Cc: 	histonet@pathology.swmed.edu
> Subject: 	Re: Histoclear
> 
> The biggest health problem I have experienced using
> histoclear is the pounding headache bought on by the
> intense pong. I know xylene is considered dangerous
> but doesn't it smell nice?!
> I have not seen any literature relating to serious
> health concerns though.
> 
> Peter.
> 
> --- NLOUISEA@aol.com wrote:
> > Hi all,
> > 
> > Has anyone experienced health problems with
> > Histoclear?  Has anything been 
> > written about it?
> > 
> > Thanks in advance.
> > Nancy
> > 
> > 
> 
> =====
> Peter Bannister
> Senior Research technician
> UCL Med. School
> London.
> __________________________________________________
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