Re: Peutz-Jagert ?

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From:lpwenk@netquest.com (Wenk, Lee & Peggy)
To:Susan Walzer <slw_histo@yahoo.com>
Reply-To:
Date:Tue, 29 Jun 1999 06:30:19 -0400
Content-Type:text/plain; charset=us-ascii

How about Peutz-Jeghers syndrome? Found this in a search 
on PubMed. (Sorry, don't know anything about it. Just 
got curious and started looking.)

It's an autosomal dominant inherited disorder characterized
by polyps in the small bowel and pigmentation of the skin
and mucous membranes. Due to the polyps, patients may have
bowel obstruction, bleeding, and repeated operations.
The more recent reports describe an increase risk for both
GI and extra-GI cancers. Women with P-J syndrome have an
extremely high risk for breast and GYN cancer. Seems to
involve the STK11 gene (also called LKB1), which encodes
for serine threonine kinase.

Some articles that looked interesting were:

Peutz-Jeghers Syndrome: a new understanding. Choi HS, Park YL,
Park JG, J Korean Med Sci 1999 Feb:14(1):2-7

Polyps as biomarkers for colorectal neoplasia. Tobi M,
Front Biosci 1999 Mar 14;4:D329-38. Review.

Peutz-Jeghers syndrome. Tomlinson IP, et al. J Med Genet.
1997 Dec;34(12):1007-11. Review.

Increased risk for cancer in patients with the Peutz-Jeghers
syndrome. Boardman LA, et al. Ann Intern Med 1998 Jun 1;
128(11):896-9.

Hope this helps. 

So - is there some special histo/IM/ISH/FISH procedure
we can do do demonstrate this?

***************************
Peggy A. Wenk, HTL(ASCP)
William Beaumont Hospital
Royal Oak, MI 48073

Susan Walzer wrote:
> 
> Does anyone know what this is? Boy, do I hate to come in to work in the
> morning and find a request for something I have never heard of!
> Thanks, Susan
> _________________________________________________________
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