Sorry if there was any confusion, our docs usually order a sort of panel
to decifer small cell v/s non-small cell.  They will order AE1/AE3, CK7,
CK20, TTF-1, NSE, Synaptophysin, and Chromogranin.

Do any of you have any other suggestions for antibodies that might help
to pin-point  small cell carcinoma?

thanks again,

Lynette Pavelich, HT(ASCP)
Histology Supervisor
Hurley Medical Center
One Hurley Plaza
Flint, MI  48503

ph:  810-257-9948
fax:  810-762-7082
>>>  06/20/07 2:56 PM >>>

We do not do just the synapto, but also chromogranin and NSE.



Roxanne Soto HT(ASCP)QIHC

Lab Supervisor


-----Original Message-----
From: Lynette Pavelich 
To: Histonet@lists.utsouthwestern.edu
Sent: Wed, 20 Jun 2007 2:31 pm
Subject: [Histonet] Small cell carcinoma




Hello,
 am curious to see what other institutions are using to diagnose small
ell carcinoma in human formalin fixed, paraffin tissue.
I have run into some literature that states that synaptophysin will
tain positive 90% of the time, and in other articles will stain
ositive only 50% of the time.  
re there other antibodies that are more specific that you have found
ork better??
Awaiting your knowledge and experience.

Lynette Pavelich, HT(ASCP)
istology Supervisor
urley Medical Center
ne Hurley Plaza
lint, MI  48503
ph:  810-257-9948
ax:  810-762-7082
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