RE: [Histonet] Small cell carcinoma

From:"Marshall Terry Dr, Consultant Histopathologist"

Ah, an H&E. What a good idea. 
A good H&E - even better idea.

In what possible circumstance other than severe crushing artefact, would
you possibly need immunochemistry for a diagnosis of small cell


-----Original Message-----
[] On Behalf Of Richard
Sent: 20 June 2007 21:12
To: Lynette Pavelich;
Subject: Re: [Histonet] Small cell carcinoma

A good H&E and, if necessary, CK8/18 (delicate, sometimes punctate
cytoplasmic reactivity) and chromogranin (rare, granular cytoplasmic
staining).  Synaptophysin is not one of my favorite antibodies due to
specificity issues.


Richard W. Cartun, Ph.D.
Director, Immunopathology & Histology
Assistant Director, Anatomic Pathology
Hartford Hospital
80 Seymour Street
Hartford, CT  06102
(860) 545-1596
(860) 545-0174 Fax

>>> "Lynette Pavelich"  06/20/07 2:31 PM >>>
I am curious to see what other institutions are using to diagnose small
cell carcinoma in human formalin fixed, paraffin tissue.

I have run into some literature that states that synaptophysin will
stain positive 90% of the time, and in other articles will stain
positive only 50% of the time.  
Are there other antibodies that are more specific that you have found
work better??

Awaiting your knowledge and experience.

Lynette Pavelich, HT(ASCP)
Histology Supervisor
Hurley Medical Center
One Hurley Plaza
Flint, MI  48503

ph:  810-257-9948
fax:  810-762-7082

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