Hi Mark:

    Yes, the stain will show apoptosis, but only if it is there. Your 
question is, "Is there apoptosis in the normal  hippocampus?" What 
species (mouse, rat, hampster, elephant)? Adult animals (>8weeks old) or 
??. What region of the hippocampus? All of these will make a difference. 
Subventricular zone might be a better choice, depending on the above.

Geoff

mark.lewis@thermo.com wrote:

>Good Monday Morning everyone,
>
>Could I expect Capsase-3 immunohistochemistry to be effective for
>detecting apoptotic cells in fixed, CONTROL hippocampal sections (in other
>words, tissue that has undergone no experimental manipulation or insult)
>
>Thanks in advance to everyone !
>
>Best regards,
>
>Mark
>
>Mark Lewis
>Product Specialist
>Anatomical Pathology
>Clinical Diagnostics
>Thermo Electron Corporation
>(412) 747-4013
>(412) 788-1097
>E-mail: mark.lewis@thermo.com
>
>
>
>
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>  
>

-- 
--
**********************************************
Geoff McAuliffe, Ph.D.
Neuroscience and Cell Biology
Robert Wood Johnson Medical School
675 Hoes Lane, Piscataway, NJ 08854
voice: (732)-235-4583; fax: -4029 
mcauliff@umdnj.edu
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