CD45 nuclear staining

From:Joe Nocito

Greetings Histoland,
    I am perplexed.  We have a squamous cell carcinoma case (poorly differentiated) that was CK 5/6 positive, p63  nuclear positive staining and CD45 nuclear positive staining.
    The background lymphocytes are staining membranous, but the tumor cells are staining positive in the nucleus. I've never seen CD45 stain nuclear in the
18 + years I've been doing this.  Not even at the AFIP did see this type of staining.  The tonsil control stained like it should.  Does anyone have an answer to this?  Thanks in advance.
Joe Nocito, BS, HT (ASCP) QIHC
Histology Supervisor
Pathology Reference Lab
San Antonio, TX

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