In a word: No.
Antibody panels, etc., with 80% of neoplasms marking for A and only 10%
marking for B, tell you nothing about the behavior of an individual neoplasm.
So far as I know no single antibody's marking pattern is pathognomonic,
serving to exclude cholangiocyte origin or to exclude large-bowel
Perhaps RFLP profiling and comparisons between samples taken from colon
neoplasm and liver neoplasm would help.
But that's not histochemistry.
We here sign out such liver-tumor cases as: Consistent with origin in
large-bowel primary (when it looks like it came from colon), see comment;
or, Consistent with origin in biliary epithelium (when it looks like a
cholangiocarcinoma), see comment.
The text of the comment is some variation on "Clinical correlation is
At 14:21 17/06/02 -0500, you wrote:
>Does anyone know how I can differentiate colonic epithelial cells from
>epithelial cells. I have a neoplasm occuring in the colon and liver. I am
>trying to decide if it is the same tumor or two different ones. Are
>antibodies out their to use with immunohistochemistry.
>MD Anderson Cancer Center
Alex Knisely, MD
Institute of Liver Studies
King's College Hospital
London SE5 9RS UK
+44 (0)20 - 7346 - 3125 telefax
+44 (0)20 - 7346 - 4627 office
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