RE: Alzheimers stain

From:"Nader, Alexander"

> HAGA is the name I have seen attached to the modified 
> methenamine silver
> method for cerebral amyloid that I mentioned.  I have assumed it was a
> contraction of 'Hexamine-(H)-Silver-(AG)-(A)'.  

I found in Bancroft & Stevens book Theory & practise of Histological

Haga C, Yamaguchi H, Ikeda K, Kosaka K 
PAM modified methenamine silver stain for senile plaques - comparison with
beta-protein immunostaining. Dementia (Japan) 1989;3:417-422.

and also:

Haga C, Ikeda K, Iwabuchi K, Akiyama H, Kondoh H, Kosaka K
Methenamine-silver staining: a simple and sensitive staining method for
senile plaques and neurofibrillary tangles.
Biotech Histochem. 1994;69(5):295-300.

so maybe Haga doesn't mean 'Hexamine-(H)-Silver-(AG)-(A)' but something else
in Japanese, I presume ;-)

BTW: What's the difference to a Sevier-Munger-stain? Can I still use it for
the detection of senile plaques? Or is it less sensitive? Maybe John
Kiernan could comment on the diagnostic differences?

Alexander Nader MD
Vienna, Austria

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