-----Original Message-----
From: Mike King [mailto:making@nersp.nerdc.ufl.edu]
Sent: 05 June 2002 16:54
To: histonet@pathology.swmed.edu
Subject: proliferation assays


Those interested in the issue of BrdU labeling for proliferating cells will
find this paper very informative.  One quote: "...neither single nor
repeated daily injections of BUdR accurately measure 'proliferation'."
Accurate measurement of proliferation variables is apparently far from
trivial.

Brain Res Dev Brain Res 2002 Mar 31;134(1-2):77-85  Dynamics of cell
proliferation in the adult dentate gyrus of two inbred strains of mice.
Hayes NL, Nowakowski RS.
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list
_uids=11947938&dopt=Abstract
Mike
       Is the  answer to  put  the  BrdU in  the  animals  water???
                                                                   Richard  Edwards

 King
UF Neuroscience
Gainesville FL