[Histonet] CYTOKERATIN QUESTION

From:"Ahmed, T (Tanni)"



Hello Histoland,

Can anyone in histoland inform me of the best cytokeratin antibody to
use to differenate squamous cell carcinoma and adenocarcinoma.? Any
feedback would be greatly appreciated.

 

Thanks in advance,

Sylinda 

________________________________

Hi Sylinda,

The best cytokeratin markers are either CK5/6 or CK7 for differentiating
squamous cell carcinoma and adenocarcinoma.

The immunohistochemical profiling panel usually consists of: 

CK7 -ve, CK5/6 +ve, CK20 -ve and TTF1 -ve  for squamous cell carcinoma

CK7 +ve, CK5/6 -ve, CK20 -ve and TTF1 +ve for adenocarcinoma

Hope this helps,

Tanni

 

 

Tanni S Ahmed

Histopathology, R&D

Intervet UK Ltd

E-mail: tanni.ahmed@intervet.com   
 

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