Try fixing your tissue in Bouin's fixative if you have the option.  The
tissue becomes a bit more rigid and easier to cut and we've never had a
problem doing immunos or histology on it.  Good luck, Sylvia 

Sylvia P. Poulos
USDA-ARS-Animal Physiology Research Unit
Athens, GA 30605
706-583-8279
706-542-0399 (fax)

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