[Histonet] copper in tissue (removing tissue from heat fixed slides)
Carmen Leschuk inquires whether it's possible to send sections for
quantitative copper determination, when the paraffin block has been exhausted.
Mayo Medical Laboratories (who probably does more of these than anybody)
requires 5 to 10 mm of paraffin-embedded liver tissue, so I'm afraid you're out of
luck.
Liver copper needs to be quantitated in Wilson's disease, a complex genetic
disease that manifests in many different ways, sometimes as chronic liver
disease with cirrhosis, sometimes as a brain disease.
I'm afraid the biopsy will have to be repeated, or the diagnosis made in some
other way.
Bob Richmond
Samurai Pathologist
Knoxville TN and Gastonia NC
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