RE: Dilated cardiomyopathy in rats

From:"Marshall Terry Dr, Consultant Histopathologist"

You can't have your cake and eat it. Either long. or cross section should show dilatation, but we are more used to appreciating it in cross section.
The heart weight is the single most useful evaluation.
No stain is of use. In dilated cardiomyopathy, a little fine interstitial fibrosis and of course, fibre hypertrophy is all that is seen.
This opinion is based on human dilated (formerly congestive) cardiomyopathy.

Dr Terry L Marshall, B.A.(Law), M.B.,Ch.B.,F.R.C.Path
 Consultant Pathologist
 Rotherham General Hospital
 South Yorkshire

-----Original Message-----
From: HSRL []
Sent: 10 July 2003 17:22
Subject: Dilated cardiomyopathy in rats

Dear Netters,


Does anyone have any experience with the histology and/or pathologic evaluation of cardiomyopathy in rats- specifically chamber dilation?  We are researching the best way to cut the heart- cross sections through the entire heart or longitudinally to show the atria and ventricles.  Also, what stains would be helpful to show this cardiomyopathy.  Any help would be greatly appreciated.





Tom Galati

Laboratory Director

HSRL- A GLP Compliant Laboratory

137 South Main Street

Woodstock, Virginia  22664


Fax: (540)459-8217


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