RE: Re - formaldehyde substitutes [Prefer] (fwd)

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From:"J. A. Kiernan" <>
To:Histonet <>
Content-Type:TEXT/PLAIN; charset=US-ASCII

Date: Wed, 5 Jul 2000 14:31:19 -0400

Please update your files. Our website address is If
you go to you will find you are at a the website of an
engineering company.

>> We had problem with prefer-fixed tissue and immunos ... have
>> discontinued use.
>  Can you tell us all what the problem was?
>  Although the exact composition of Anatech's "Prefer" fixative
>  is a trade secret, its active ingredient (glyoxal) and mode
>  of action (aldehyde reactivity similar to formaldehyde's) are
>  clearly explained in Anatech's literature (
>  and in some peer-reviewed publications (e.g. Dapson, 1993
>  Biotech Histochem 68:75-82). Glyoxal fixation has also been
>  explained in various HistoNet messages that should be findable
>  in the Archives.
>  Any problem encountered with a glyoxal-based fixative but not
>  with formaldehyde would be of general interest. So, for that
>  matter, would any applications for which glyoxal turns out
>  to give better fixation or antigen preservation.

Ada T. Feldman MS, HT/HTL(ASCP)
Director of Manufacturing & Technical Services
1020 Harts Lake Road
Battle Creek, MI  49015
800-262-8324 or 616-964-6450
Fax 616-964-8084

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