Re: Hale's colloidal iron

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Got a reply from Gerry del Junco (don't know where): about why pathologists
seem suddenly to be ordering colloidal iron stains.

The article del Junco cites is:

Colloidal iron staining in renal epithelial neoplasms, including chromophobe
renal cell carcinoma: emphasis on technique and patterns of staining.
Satish K Tickoo, Mahul B Amin, Richard J Zarbo (Henry Ford Hosp, Detroit MI).
Am J Surg Pathol 1998:22;419-424.

The article claims that chromophobe renal cell carcinomas stain strongly, as
do other renal cell carcinomas, while oncocytomas stain weakly. This
distinction is of great clinical importance because oncocytomas are benign
(and rare), while renal cell carcinomas are highly malignant (and common). I
do not find the article very convincing.

Special modifications of the colloidal iron stain are needed, and pathologists
wanting to try this technique out should review the methods section of the
article with their histotechnologists before having them proceed.

Bob Richmond
Samurai Pathologist
Knoxville TN

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