Shrinkage of formalin fixed tissue

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From:stewart abrams-engeman <> (by way of histonet)
To:histonet <>
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Is there a general rule of thumb to predict the degree of tissue shrinkage
following formalin fixation and standard processing with paraffin embedding?
More specifically, what can be said regarding the shrinkage of a length of
medium sized artery ( e.g. popliteal) after such fixation and processing?
Do you have references?
Thanks for any help you can give me.

Karyn Abrams-Engeman
Evanston Northwestern Heathcare

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