RE: [Histonet] Re: HER2 fixation time

From:"Weems, Joyce"

Our Medical Director called to find out how this time was determined. It was just randomly chosen - obviously without consideration of the labs that are not open on Sat. If everyone starts changing things - even with documentation - we lose the attempt at standardization. Just have someone remove the blocks from the processor and everyone will have followed the standards! My 2 cents again... JJoyce WeemsPathology ManagerSaint Joseph's Hospital 5665 Peachtree Dunwoody Rd NEAtlanta, GA 30342404-851-7376 - Phone404-851-7831 - Fax-----Original Message-----From: [] On Behalf Of Della Speranza, VinnieSent: Friday, January 25, 2008 10:35 AMTo: Rene J Buesa; Dawson, GlenCc: histonet@lists.utsouthwestern.eduSubject: RE: [Histonet] Re: HER2 fixation timeI think we are forgetting that this "qualitative result" has large therapeutic implications for the patient. If your results are different from mine, are we really doing our best for the patient?This is the whole premise behind the attempt to standardize and frankly you have to start somewhere, so why not fixation? I for one am fine with the additional headache of working out the fixation tracking if it helps just one individual. But like many of you I do hope that the fixation time limit is expanded beyond 48 hours.Vinnie Della SperanzaManager for Anatomic Pathology Services165 Ashley Avenue  Suite 309Charleston, South Carolina 29425Tel: (843) 792-6353Fax: (843) 792-8974 -----Original Message-----From: [] On Behalf Of Rene J BuesaSent: Thursday, January 24, 2008 2:37 PMTo: Dawson, GlenCc: histonet@lists.utsouthwestern.eduSubject: RE: [Histonet] Re: HER2 fixation timeIs now "Big brother" in the histology business?   All this standardization to get to a QUALITATIVE result?   Where are the "standard" photomicrographs printed identically with the same standard color quality prints to compare with?  I know of two color blind pathologists and three with poor vision.  René J."Dawson, Glen"  wrote:  All,Once we all agree to fix our tissues for EXACTLY the same amount of time in the same fixative (supplied by the same vendor of course), what do we do with all of the other factors involved to reach this pipe dream of national standardization? The next step must be a requirement for all of us to work in the same hermetically sealed, mass produced "pre-fab" labs that can all provide identical water sources, temperatures, humidity, elevation/pressure, etc... We must all agree to use identical antigen retrieval methods, kits/detections, chromagens, etc... provided by the same "super vendor" with the same lot numbers. This may be feasable with all the buyouts in our industry but remains highly unlikely. Lastly, we must all agree to invite in only the same gremlins since they seem to thrive in so many laboratory environments.My point is, the new CAP HER2 guidlines are a fruitless attempt to standardize a procedure that has too many factors involved to achieve true, nation-wide standardization. The current discussion on the fixation aspect needs to be tempered by the fact that it is still only one factor in many.Does anyone else get that sick feeling that this is just the tip of the iceburg and calls for pre-fab kits and national standardization for many other tests are just around the corner?Things that make you go HMMMMMM,Glen Dawson BS, HT & QIHC (ASCP)IHC ManagerMilwaukee, WI _______________________________________________Histonet mailing listHistonet@lists.utsouthwestern.edu       ---------------------------------Never miss a thing.   Make Yahoo your homepage._______________________________________________Histonet mailing listHistonet@lists.utsouthwestern.edu mailing listHistonet@lists.utsouthwestern.edu Notice ** The information contained in this message may be privileged and is confidential information intended for the use of the addressee listed above. If you are neither the intended recipient nor the employee or agent responsible for delivering this message to the intended recipient, you are hereby notified that any disclosure, copying, distribution or the taking of any action in reliance on the contents of this information is strictly prohibited. If you have received this communication in error, please notify us immediately by replying to the message and deleting it from your computer. Thank you. Saint Joseph's Health System, Inc.

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