[Histonet] Re: HER2 and the 48 hour rule
Here's a truly radical solution: if the pathologist on call comes in on
Saturday (or Sunday) morning, let the pathologist embed the breast biopsies! It's
about time pathologists learned to embed.
Short of that revolutionary approach, I'd want the tissue to fix overnight,
then be passed to 70% alcohol, then processed Sunday night. - But it isn't
known that this approach works, and it doesn't comply with the rules (which aren't
new, actually). But it's got to be preferable to leaving the specimen in
xylene (or substitute) or in molten wax.
Don't forget the issue of non-formalin fixatives, including glyoxal - they
haven't been tried.
I'm more concerned about tissue that isn't left in formalin for long enough.
If it's not, it fixes in the processor in alcohol. I'm even more concerned
about delay in fixation. In many radiology services, stereotactic and
wire-localization specimens aren't placed in formalin until after specimen radiography is
completed and the specimen is leisurely taken to the pathology lab.
I was appalled, but not surprised, by the CAP's failure to address any of
Let's remind ourselves what's at stake here. HER2 status determines whether a
patient is treated with trastuzumab (Herceptin), a $50,000 treatment with a
potential for damaging the heart. Estrogen receptor determination is also
affected by fixation, and expensive and hazardous treatment depends on that also.
The lack of concern about this issue by primary care physicians, surgeons,
and oncologists once again underlines the "redhaired stepchild" status of
anatomic pathology in the laboratory and in the health care system. Remember that
when you read the newspapers and magazines and read that faceless "technicians"
are responsible for all of these procedures.
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