[Histonet] Re: Blue Nevus Disease-Help?


Scheherazade Humphrey asks about possible immunohistochemical staining of a 
blue nevus.

Blue nevus -   an uncommon but not rare benign variant of pigmented nevus - 
should mark for S100, but it's nearly always an H & E diagnosis. The usual blue 
nevus isn't a disease, just an isolated skin lesion. Bundles of heavily 
pigmented spindly melanocytes are present in the dermis but there are usually no 
nevus cell nests in the basal layer of the epidermis, so the pigment looks 
bluish when you look at the nevus "on the hoof".

Scheherazade - what a name - since my wife's a storyteller - I hear 
Scheherazade's narrator theme, first stated (I think) by the violin - in Nikolai 
Rimsky-Korsakoff's orchestral suite of that name - one of my parents' favorite 
classical pieces, on those fragile old 78 rpm shellac records back when I was a kid 
in the 1940's -

Bob Richmond
Samurai Pathologist
Knoxville TN
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